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Risk of progression in IgA nephropathy

A UK Retrospective Cohort Found That Patients With Higher Levels of Time-averaged Proteinuria Had More Rapid eGFR Loss1,*,†


Even proteinuria levels typically perceived as low risk (<0.88 g/g) may also indicate a risk of disease progression1

Click on image to enlarge.

<0.88 g/g is approximately equivalent to <1 g/day.1

Image adapted from: Pitcher D, Braddon F, Hendry B, et al. Long-term outcomes in IgA nephropathy. Clin J Am Soc Nephrol. 2023;18(6):727-738. doi:10.2215/CJN.0000000000000135

A UK retrospective cohort found that 30% of patients with a time-averaged proteinuria range of 0.44 to <0.88 g/g reached kidney failure within 10 years1,*

Click on image to enlarge.

<0.88 g/g is approximately equivalent to <1 g/day.1

Image adapted from: Pitcher D, Braddon F, Hendry B, et al. Long-term outcomes in IgA nephropathy. Clin J Am Soc Nephrol. 2023;18(6):727-738. doi:10.2215/CJN.0000000000000135

In all age groups, the majority of patients developed kidney failure in 10 to 15 years1

See the mechanism of disease (MOD) for IgAN in action

View the MOD for IgA nephropathy

Explore the burden of patients living with IgAN

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eGFR, estimated glomerular filtration rate; IgAN, immunoglobulin A nephropathy; IQR, interquartile range; UPCR, urine protein-creatinine ratio.

Reference: 1. Pitcher D, Braddon F, Hendry B, et al. Long-term outcomes in IgA nephropathy. Clin J Am Soc Nephrol. 2023;18(6):727-738. doi:10.2215/CJN.0000000000000135